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Molsoft ICM empowers a biologist or chemist with lightning fast access and high quality interactive 3D views to the entire structural database. In just a few seconds you can browse hundreds of structures of interest load them, analyze and visualize sequences, structures, alignments, sites, study pockets and bound ligands and drugs, study surfaces, electrostatics, mutations, pockets, sequence conservations, perform docking of small molecules as well as protein-protein docking. ICM supports multiple input formats. You can search structural database by field, sequence pattern and get an interactive table for instant viewing. ICM offers a rich graphical environment and powerful views for professional quality of images and molecular animation videos.

The ICM ("Internal Coordinate Mechanics") software project was originally designed around a new molecular mechanics approach and optimization algorithm for peptide prediction, homology modeling, loop simulations, flexible macromolecular docking and refinement, and then was extended to graphics, molecular animations, chemistry, sequence analysis, database searches, mathematics, statistics and plotting. ICM-Pro contains an all atom internal coordinate force field and efficient algorithm to perform local and global energy optimization of small or large molecules with respect to an arbitrary subset of variables. In addition, ICM contains MMFF94 force field for energy optimization in Cartesian space for any organic molecule. ICM-Pro allows users to read, build, convert, refine, analyze and superimpose molecules. Includes graphics tools for diverse molecular rendering, perspective viewing, depth cueing, etc. Uses both hardware and side-by-side stereo. Allows saving and printing a screen image as a compact vectorized post file in addition to a compressed bitmap.